The university was founded as a school of systems engineering, IT (Information Technology) and computer science (FISICC) of the Universidad Francisco Marroquín. In 1977 the faculty created the foundation Santo Domingo, which came to assist in the educational, technological, cultural and artistic heritage of Guatemala. After 22 years, the foundation initiated procedures for the approval of a new university. It was authorized by the Superior Council of Private Education on October 31, 2000 as a university. The name honors astronomer and mathematician Galileo Galilei.
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